IGF2BP3 promotes autophagy-mediated TNBC metastasis via m6A-dependent, cap-independent c-Met translation
Our study expands the understanding of IGF2BP3's role in TNBC metastasis by establishing its function in regulating autophagy. Notably, IGF2BP3 could bind to the m6A motif on the 5' and 3' untranslated regions (UTRs) of c-Met mRNA to facilitate its translation in a cap-independent manner.
Authors
- Yi-Han Li
- Xu Zhang (ORCID: https://orcid.org/0000-0002-3553-6820)
- Qiang Ding (ORCID: https://orcid.org/0000-0003-1499-6200)
- Ji‐Fu Wei (ORCID: https://orcid.org/0000-0001-6412-3251)
- Mengyuan Cai (ORCID: https://orcid.org/0000-0002-1152-5895)
- Ziwen Wang (ORCID: https://orcid.org/0000-0001-9798-7021)
- Haiyan Yang (ORCID: https://orcid.org/0000-0002-3036-3000)
- Liang Shi (ORCID: https://orcid.org/0000-0002-1662-8367)
- Yuzhou Huang (ORCID: https://orcid.org/0000-0002-2818-867X)
- Ruo-Xi Xu
Institutions
- Nanjing Medical University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1186/s12964-025-02316-7
- Citations
- 5
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Science and Technology Support Program of Jiangsu Province
- Jiangsu Cancer Hospital