ACPA-Induced ATP release and K+ efflux trigger NLRP3 inflammasome activation in rheumatoid arthritis
Our study demonstrates that ACPA can trigger both the priming and activation of the NLRP3 inflammasome. This process involves the release of ATP and the efflux of K<sup>+</sup>.
Authors
- Shixian Chen (ORCID: https://orcid.org/0000-0002-7200-433X)
- Jian Gao (ORCID: https://orcid.org/0000-0001-5059-2698)
- Xiangyun Meng
- Bing Xiao (ORCID: https://orcid.org/0000-0002-3350-2678)
- Kai Zhang (ORCID: https://orcid.org/0000-0001-5235-4562)
- Zhipeng Chen (ORCID: https://orcid.org/0009-0003-3496-0624)
- Xiaoling Chen (ORCID: https://orcid.org/0000-0001-8226-8446)
- Juan Li (ORCID: https://orcid.org/0000-0002-2977-2966)
- Meng Li (ORCID: https://orcid.org/0000-0002-0336-9271)
- Cai Li (ORCID: https://orcid.org/0000-0002-3079-1451)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Nanjing University of Chinese Medicine (CN)
- Guangzhou University (CN)
- Nanfang Hospital (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1186/s12964-025-02331-8
- Citations
- 6
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- National Natural Science Foundation of China