STING regulates NETs formation by activating GSDMD in influenza viral pneumonia
Our study demonstrated that targeted intervention with STING alleviated pneumonia by inhibiting inflammation and NETs formation. The study also revealed that blocking STING could inhibit the activation of GSDMD to inhibit NETs formation, slowing the progression of viral pneumonia.
Authors
- Junsong Jing
- Lijuan Xing (ORCID: https://orcid.org/0009-0007-6582-355X)
- Rongrong Huang (ORCID: https://orcid.org/0000-0002-9730-7898)
- Sheng Zhang (ORCID: https://orcid.org/0000-0002-3041-5026)
- Yueguo Wu (ORCID: https://orcid.org/0000-0002-4761-8532)
- Wenwen Zhu (ORCID: https://orcid.org/0000-0003-0306-3325)
- Zhenqiang You (ORCID: https://orcid.org/0000-0002-4167-6598)
- Ranran Chen (ORCID: https://orcid.org/0000-0003-3216-2373)
- Ting Zhou (ORCID: https://orcid.org/0009-0008-9576-0569)
- Lianhao Wu
Institutions
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-07-01
- DOI
- https://doi.org/10.3389/fimmu.2025.1598902
- Citations
- 1
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- National Natural Science Foundation of China