Human neutrophil lipocalin, procalcitonin, c-reactive protein, and leucocyte count for prediction of bacterial sepsis in emergency department patients
Our findings do not support the routine use of serum HNL as a tool in the prediction of bacterial sepsis in patients presenting to the ED. A combination of biomarkers (serum HNL or CRP plus leucocytes) with NEWS and SOFA at presentation outperformed inflammatory biomarkers used individually in the prediction of bacterial sepsis.
Authors
- Christian H. Nickel (ORCID: https://orcid.org/0000-0001-6619-9284)
- Tobias Kuster (ORCID: https://orcid.org/0000-0001-6702-9965)
- Christiane Rosin
- G Balestra (ORCID: https://orcid.org/0000-0002-5862-0435)
- Roland Bingisser (ORCID: https://orcid.org/0000-0001-8223-9792)
- Kriemhild Lippay
- Alina Lampart
- Ricardo Nieves-Ortega (ORCID: https://orcid.org/0000-0003-1619-3401)
- Christoph Becker (ORCID: https://orcid.org/0000-0001-6039-4003)
- Jonathan Benhamou
Institutions
- University Hospital of Basel (CH)
- Hospital Base (CL)
Publication Details
- Journal
- Scandinavian Journal of Trauma Resuscitation and Emergency Medicine
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1186/s13049-025-01429-9
- Citations
- 2
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- Universität Basel