The mediating factors between systemic lupus erythematosus and prostate cancer risk: a two-step Mendelian randomization and transcriptome analysis
Our study once again emphasizes the protective effect of SLE on PCa and confirms the mediating role of sex hormone and immune-cells, and highlights TOR1B as a potential therapeutic target for PCa.
Authors
- Siwen Zhong
- Fa Sun (ORCID: https://orcid.org/0000-0003-3556-0131)
- Yuewei Tao (ORCID: https://orcid.org/0000-0002-8059-8000)
- Quliang Zhong (ORCID: https://orcid.org/0000-0001-7313-004X)
- Peng Chen (ORCID: https://orcid.org/0009-0003-2359-8690)
- Jun Qiao (ORCID: https://orcid.org/0000-0002-1772-5003)
- Wei Li (ORCID: https://orcid.org/0009-0007-2619-3495)
- Yuan Tian (ORCID: https://orcid.org/0000-0002-5291-3202)
- Tao Li (ORCID: https://orcid.org/0009-0006-6811-2182)
- Xingliang Yang
Institutions
- Guiyang Medical University (CN)
- Army Medical University (CN)
- University of Dundee (GB)
- Ninewells Hospital (GB)
- Affiliated Hospital of Guizhou Medical University (CN)
- Xinqiao Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1007/s12672-025-03046-5
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health Commission of Guizhou Province
- National Natural Science Foundation of China
- Guizhou Medical University