Anti-inflammatory and renoprotective effects of difelikefalin, a kappa opioid receptor agonist, in a rat model of renal ischemia–reperfusion-induced acute kidney injury

These findings indicate that difelikefalin has anti-inflammatory and renoprotective effects in a rat acute kidney injury model, with varying anti-inflammatory efficacy among KOR agonists.

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Publication Details

Journal
BMC Nephrology
Published
2025-07-01
DOI
https://doi.org/10.1186/s12882-025-04199-9
Citations
1
Primary Topic
Acute Kidney Injury Research
Type
article
Field-Weighted Citation Impact
1.43
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article

Anti-inflammatory and renoprotective effects of difelikefalin, a kappa opioid receptor agonist, in a rat model of renal ischemia–reperfusion-induced acute kidney injury

Hiroto Takeuchi, Satoshi Tatemichi, Yuji Okuhara
1 citations
BMC Nephrology
Acute Kidney Injury Research
1.43
article

Anti-inflammatory and renoprotective effects of difelikefalin, a kappa opioid receptor agonist, in a rat model of renal ischemia–reperfusion-induced acute kidney injury

Hiroto Takeuchi, Satoshi Tatemichi, Yuji Okuhara
article en
1 citations

Abstract

These findings indicate that difelikefalin has anti-inflammatory and renoprotective effects in a rat acute kidney injury model, with varying anti-inflammatory efficacy among KOR agonists.

BMC NephrologyVol. 26(1)
Kissei Pharmaceutical (Japan) (JP)
Good health and well-being
Openalex Percentile: Top 18%
Acute Kidney Injury Research
1.43
DOIOpen Access PDFOpenAlex
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Anti-inflammatory and renoprotective effects of difelikefalin, a kappa opioid receptor agonist, in a rat model of renal ischemia–reperfusion-induced acute kidney injury — Hiroto Takeuchi, Satoshi Tatemichi, et al. · BMC Nephrology (2025) | TGRS Research Map | TGRS