Diagnostic value of hsa_circ_0012138 in the chronic progression of obstructive nephropathy

In this study we identified hsa_circ_0012138 expression in the kidney tissue by RT-qPCR. By GSEA enrichment, we speculated that it may regulate the expression of multiple target genes related to renal fibrosis through ceRNA mechanism. We further detected its expression in urine of ON patients with different stage. Combined with the other clinical variables, statistical analysis found that, compared with NAGL, hsa_circ_0012138 has good specificity and sensitivity in prediction the renal function reversibility after kidney-sparing surgery in ON patients, and is expected to be used as a prognostic marker to guide surgical decision-making.