Amentoflavone Impedes NF-κB Activation and Mediates Apoptosis Induction in Lung Cancer Cells: An in vitro and in silico exploration
Thus, it was concluded that AMF exerts potent anticancer effects in NSCLC A549 cells through dual mechanism such as direct inhibition of NF-κB signaling and apoptosis induction combined with its high binding affinity, positions it as a promising therapeutic candidate for NSCLC. Further preclinical studies are warranted to validate these findings.
Authors
- Rohit Kumar Tiwari (ORCID: https://orcid.org/0000-0001-8215-633X)
- Gaurav Kaushik (ORCID: https://orcid.org/0000-0001-6743-7811)
- Afza Ahmad (ORCID: https://orcid.org/0000-0002-3432-5239)
- Syed Shah Mohammed Faiyaz (ORCID: https://orcid.org/0000-0002-7558-0834)
- Chaitenya Verma (ORCID: https://orcid.org/0000-0001-5723-6346)
- Syed Monowar Alam Shahid (ORCID: https://orcid.org/0000-0002-6904-0815)
- Vinay Kumar (ORCID: https://orcid.org/0000-0002-6751-5741)
- Daniya Fatima
Institutions
- University of Lucknow (IN)
- University of Ha'il (SA)
- Dr. D. Y. Patil Medical College, Hospital and Research Centre (IN)
- Sharda University (IN)
- Penn State Milton S. Hershey Medical Center (US)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-07-01
- DOI
- https://doi.org/10.2147/jir.s521756
- Citations
- 1
- Primary Topic
- Biological Activity of Diterpenoids and Biflavonoids
- Type
- article
- Field-Weighted Citation Impact
- 0.81