The stromal vascular fraction mitigates bleomycin-induced skin fibrosis in mice by modulating vascular lesions and secreting antifibrotic factors at different stages of disease
SVF, particularly its CD45-negative subset, holds considerable promise for the treatment of SSc-associated skin fibrosis. These findings suggest that SVF-based therapies could be effective in managing fibrosis-related diseases and offer valuable insights for future clinical applications.
Authors
- Yahui Chen (ORCID: https://orcid.org/0000-0002-8647-6856)
- Jiucun Wang (ORCID: https://orcid.org/0000-0003-2765-0620)
- Min Shi (ORCID: https://orcid.org/0000-0002-2130-181X)
- Xiangguang Shi (ORCID: https://orcid.org/0000-0002-3907-5822)
- Zonghao Liu (ORCID: https://orcid.org/0009-0000-3456-1381)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fudan University (CN)
- Huashan Hospital (CN)
- Medical Technologies (Czechia) (CZ)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1186/s13287-025-04470-8
- Citations
- 1
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- National Natural Science Foundation of China
- Chinese Academy of Medical Sciences
- National Key Research and Development Program of China