Immune Cell Characteristics in a Gut-Kidney Axis-Induced Mouse Model of IgA Nephropathy: The Upregulated Dendritic Cells and Neutrophils
The gut-kidney axis, including microbiota homeostasis and innate immune cell response, contributes to the pathogenesis of IgAN. Gut dysbiosis and hyperactivated immune cells like CD11c<sup>+</sup>dendritic cells can affect the mucosal barrier and exacerbate the renal damage, being novel insights into immunotherapeutic strategies for IgAN.
Authors
- Yuna Chen
- Qijun Wan (ORCID: https://orcid.org/0000-0002-5039-4015)
- Jiaqi Liu (ORCID: https://orcid.org/0000-0002-8927-8003)
Institutions
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-07-01
- DOI
- https://doi.org/10.2147/jir.s519521
- Citations
- 3
- Primary Topic
- Immune responses and vaccinations
- Type
- article
- Field-Weighted Citation Impact
- 2.39