Renal cell carcinoma with fibromyomatous stroma (<scp>RCC FMS</scp>) and with hemangioblastoma‐like areas is part of the <scp>RCC FMS</scp> spectrum in patients with tuberous sclerosis complex
HB-like morphology found in RCC FMS in TSC patients represents part of the morphologic spectrum of RCC FMS, which is a previously underreported and underrecognized feature. RCC FMS with HB-like areas show uniform GPNMB reactivity and are associated with TSC/MTOR alterations, but not with VHL alterations.
Authors
- Jacob Houpt (ORCID: https://orcid.org/0000-0002-7505-0681)
- Douglas J. Mahoney (ORCID: https://orcid.org/0000-0002-0642-992X)
- Kiril Trpkov (ORCID: https://orcid.org/0000-0003-3142-8846)
- Manal Gabril (ORCID: https://orcid.org/0000-0002-4133-992X)
- Rola Saleeb (ORCID: https://orcid.org/0000-0002-1937-3101)
- Daniel J. Arnold
- Madeleine Moussa (ORCID: https://orcid.org/0000-0003-4786-6226)
- Franz J. Zemp (ORCID: https://orcid.org/0000-0002-8845-3535)
- Farshid Siadat (ORCID: https://orcid.org/0000-0001-7676-4806)
- José A. Gómez
- Andrew A. House (ORCID: https://orcid.org/0000-0001-7152-6163)
- Katherina Baranova (ORCID: https://orcid.org/0000-0003-4740-9789)
- Haiying Chen
- Aslı Yilmaz (ORCID: https://orcid.org/0000-0003-4148-8316)
- Adrian Box
- Stephen E. Pautler (ORCID: https://orcid.org/0000-0001-9281-8122)
- Laura Lockau
- Lindsay Ninivirta
Institutions
- Western University (CA)
- University of Calgary (CA)
- University of Toronto (CA)
- London Health Sciences Centre (CA)
- Alberta Children's Hospital (CA)
Publication Details
- Journal
- Histopathology
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1111/his.15505
- Citations
- 6
- Primary Topic
- Tuberous Sclerosis Complex Research
- Type
- article
- Field-Weighted Citation Impact
- 6.99