Mesenchymal stem cell-derived apoptotic vesicles regulate irritable bowel syndrome in mice via the 5-HT brain-gut axis
Our findings suggest that apoVs act as novel messengers in brain-gut axis interactions, regulating brain-gut homeostasis. This study provides a new therapeutic approach for the treatment of functional gastrointestinal disorders like IBS.
Authors
- Xueli Mao (ORCID: https://orcid.org/0000-0002-2611-7712)
- Yijun Zhang (ORCID: https://orcid.org/0000-0001-9664-7359)
- Ya Sun
- Xuanyi Li (ORCID: https://orcid.org/0000-0003-4367-3005)
- Di Wu (ORCID: https://orcid.org/0000-0002-5151-6010)
- Lu Lu (ORCID: https://orcid.org/0000-0002-0960-1529)
- Jinyang Wang (ORCID: https://orcid.org/0009-0005-8949-3079)
Institutions
- Macau University of Science and Technology (MO)
- Chinese Academy of Sciences (CN)
- Stomatology Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1186/s13287-025-04448-6
- Citations
- 3
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 5.43
Funders
- Key Technologies Research and Development Program
- National Key Research and Development Program of China
- Basic and Applied Basic Research Foundation of Guangdong Province