Brain targeted lipid nanoparticles with Hv1 inhibitors alleviate neuroinflammation post-ischemic stroke
T7-LNP@YHV984 multifunctional nanoparticles with long-term stability emerged as a potent strategy to alleviate reperfusion injury and inhibit neuroinflammation post-IS. By precisely targeting Hv1 in microglia, the nanoparticles effectively suppressed microglia-induced neuroinflammation, minimizing off-target effects. This innovation offers novel insights into stroke treatment and neuroprotective strategies.
Authors
- Liyan Li (ORCID: https://orcid.org/0000-0002-2411-4235)
- Ran Li (ORCID: https://orcid.org/0000-0002-0647-2557)
- Zeyu Yang (ORCID: https://orcid.org/0009-0006-9681-5184)
- Boyang Wei (ORCID: https://orcid.org/0000-0003-1252-8200)
- Shenquan Guo (ORCID: https://orcid.org/0000-0002-6952-9821)
- Chuanzhi Duan (ORCID: https://orcid.org/0000-0002-2025-8637)
- Lei Jin (ORCID: https://orcid.org/0000-0003-3254-9105)
- Yu Na Wu (ORCID: https://orcid.org/0009-0005-6814-3280)
- Fa Jin (ORCID: https://orcid.org/0000-0002-2470-2942)
- Longxiang Li (ORCID: https://orcid.org/0000-0002-6630-7713)
- Wenchao Liu (ORCID: https://orcid.org/0000-0001-5600-8253)
- Yanan Wang (ORCID: https://orcid.org/0000-0002-0327-0458)
- Xifeng Li (ORCID: https://orcid.org/0000-0003-4393-1916)
- Yiming Bi (ORCID: https://orcid.org/0000-0002-0436-5301)
- Yanchao Liu (ORCID: https://orcid.org/0000-0003-2053-7289)
- Xin Feng (ORCID: https://orcid.org/0009-0003-9276-2319)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Sun Yat-sen University (CN)
- Zhujiang Hospital (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1186/s12951-025-03540-6
- Citations
- 4
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 2.70
Funders
- National Natural Science Foundation of China
- National Health and Family Planning Commission of the People's Republic of China
- National Health Commission of the People's Republic of China