Ocular neuromodulation as a novel treatment for retinitis pigmentosa: identifying rod responders and predictors of visual improvement

Ocular neuromodulation significantly improved night vision, BCVA, and contrast sensitivity. Determinants of rod responders include the duration of night blindness, stage of the disease, and thickness of ganglion cell layer at baseline. Two therapeutic scenarios were recognized; an early disease-modifying intervention that restores night vision and a late cone rescue intervention that improves/maintains central vision.