Glymphatic and neurofluidic dysfunction in classical trigeminal neuralgia: a multimodal MRI study of brain-CSF functional and structural dynamics
This study provides multimodal MRI evidence of glymphatic dysfunction and neurofluidic alterations in CTN, supporting a conceptual framework in which disrupted brain-CSF interaction may influence peripheral sensory modulation through a putative brain-CSF-ganglion pathway. These results may inform mechanistic hypotheses and guide future research on the neurofluidic underpinnings of neuropathic pain, potentially providing new insights into the pathogenesis of CTN.
Authors
- Fenyang Chen
- Jun Miao (ORCID: https://orcid.org/0000-0002-9429-4681)
- Y. Zhang (ORCID: https://orcid.org/0000-0002-0452-0412)
- Zhongxiang Ding (ORCID: https://orcid.org/0000-0001-7691-5571)
- Haiqi Ye
- Lei Pan (ORCID: https://orcid.org/0000-0002-1111-5570)
- Zhiliang Zhang (ORCID: https://orcid.org/0000-0002-9557-3455)
- Juncheng Yan
- Xiuhong Ge
- Ding Wang
Institutions
- United States Air Force (US)
- Zhejiang Hospital (CN)
- Shaoxing People's Hospital (CN)
Publication Details
- Journal
- BMC Medical Imaging
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1186/s12880-025-01801-2
- Citations
- 1
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- Natural Science Foundation of Zhejiang Province