Central position of histidine in the sequence of designed alternating polarity peptides enhances pH-responsive assembly with DNA
These findings highlight the importance of histidine positioning within peptide sequences for tuning pH-responsiveness and optimizing DNA co-assembly and transfection efficiency. The results provide valuable insights for the rational design of efficient, safe, and pH-responsive peptide-based gene delivery systems.
Authors
- Arash Arashkia (ORCID: https://orcid.org/0000-0002-3117-3217)
- Nasir Mohajel (ORCID: https://orcid.org/0000-0001-8883-4429)
- Razieh Taghizadeh Pirposhteh (ORCID: https://orcid.org/0000-0003-3760-4230)
- M Masoumi (ORCID: https://orcid.org/0000-0002-6182-0980)
- Kayhan Azadmanesh (ORCID: https://orcid.org/0000-0002-7165-9043)
Institutions
- Pasteur Institute of Iran (IR)
Publication Details
- Journal
- BMC Biotechnology
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1186/s12896-025-00976-4
- Citations
- 5
- Primary Topic
- Antimicrobial Peptides and Activities
- Type
- article
- Field-Weighted Citation Impact
- 5.92
Funders
- National Science Foundation
- Iran National Science Foundation
- Tehran University of Medical Sciences and Health Services
- Centre National de la Recherche Scientifique
- Pasteur Institute of Iran