Aurantio-obtusin modulates Wilms Tumour 1 within the breast tumour microenvironment reducing immunosuppression and tumour growth
Therapeutic targeting of the WT1/STAT1/3/PD-L1/IDO axis in CAFs with AO has the potential to enhance T cell activity and reduce Treg percentage within the TME, thereby enhancing tumour immunity and reducing tumourigenesis.
Authors
- Laura R. Barkley (ORCID: https://orcid.org/0000-0001-8026-5284)
- Vatsal Kumar (ORCID: https://orcid.org/0000-0003-1302-328X)
- Michael J. Kerin (ORCID: https://orcid.org/0000-0003-4164-5561)
- Dómhnall J O'Connor (ORCID: https://orcid.org/0000-0003-1208-9869)
- Ning Ge (ORCID: https://orcid.org/0000-0001-8407-2439)
- Eóin McEvoy (ORCID: https://orcid.org/0000-0002-8804-8177)
- Barry Digby (ORCID: https://orcid.org/0000-0002-8492-6585)
- Xiao Hu (ORCID: https://orcid.org/0000-0003-1128-4099)
- Paul Loftus
- Pilib Ó Broin (ORCID: https://orcid.org/0000-0002-6702-8564)
- Stephen J. Elliman (ORCID: https://orcid.org/0000-0003-2121-8407)
- Zhilin Li (ORCID: https://orcid.org/0000-0002-1636-5376)
Institutions
- Northwestern University (US)
- Ollscoil na Gaillimhe – University of Galway (IE)
- Orbsen Therapeutics (Ireland) (IE)
- Shanghai Institute of Pharmaceutical Industry (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1186/s12964-025-02292-y
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Science Foundation Ireland
- China Scholarship Council