Tensile stress promotes the chondrogenic ability of condylar cartilage stem/progenitor cells in the temporomandibular joint via the Piezo1-Ca2+-Prkca pathway
We uncovered that tensile stress could cause a transient shrinkage of the CSPCs pool in condylar cartilage, resulting from the accelerated chondrogenesis of CSPCs. Tensile force could promote the chondrogenic ability of CSPCs via the Piezo1-Ca<sup>2+</sup>-Prkca pathway. This study suggested a new regulatory route for mandibular growth modification in orthodontic practice.
Authors
- Xiaohui Mi (ORCID: https://orcid.org/0000-0002-1820-7961)
- Huimin Chu (ORCID: https://orcid.org/0000-0002-8621-0708)
- Zhan‐Peng Yue (ORCID: https://orcid.org/0000-0001-6776-9015)
- Yongming Li
- Wuyi Gong (ORCID: https://orcid.org/0000-0002-5418-2888)
Institutions
- Tongji University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1186/s13287-025-04439-7
- Citations
- 5
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 5.82
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality