The circ_0054633/miR-590-3p/RUNX2 positive feedback loop promotes the osteogenic differentiation of BMSCs
Our results suggest that the circ_0054633/miR-590-3p/RUNX2 positive feedback loop promotes the osteogenic differentiation of BMSCs and is expected to be a potential biomarker and therapeutic target for bone regeneration in T2DM.
Authors
- Yang Liu (ORCID: https://orcid.org/0000-0002-5694-8760)
- Zongli Diao (ORCID: https://orcid.org/0000-0002-5019-9009)
- Haoqing Yang (ORCID: https://orcid.org/0000-0003-1662-9420)
- Zhenhua Gao (ORCID: https://orcid.org/0000-0001-8314-4904)
- Zhaochen Shan (ORCID: https://orcid.org/0000-0003-3990-9011)
- Yue Zhang (ORCID: https://orcid.org/0009-0004-2109-9190)
- Xiangnan Li (ORCID: https://orcid.org/0000-0003-0417-9151)
- Lingxiao Wang (ORCID: https://orcid.org/0000-0003-3757-3403)
- Yishu Huang (ORCID: https://orcid.org/0000-0002-4314-4288)
- Bowen Zhou (ORCID: https://orcid.org/0000-0003-1062-9526)
Institutions
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Shanghai Stomatological Hospital (CN)
- Stomatology Hospital (CN)
- Cells Therapy (Poland) (PL)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1186/s13287-025-04450-y
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Capital Medical University
- National Key Research and Development Program of China