Arhgef7 as a key target for enriched environment rescuing spatial cognitive deficits and anxiety-like behaviors in a mouse model of Alzheimer’s disease following early social isolation
Arhgef7 in mPFC neurons is essential for the physical components of EE selectively alleviating spatial cognitive deficits and anxiety-like behaviors in early isolated AD model mice, serving as a potential target for the prevention and treatment of AD.
Authors
- Ming Xiao (ORCID: https://orcid.org/0000-0001-5528-9102)
- Shixin Ding (ORCID: https://orcid.org/0000-0001-8224-4735)
- Yuxi Jin
- Shuying Zhang (ORCID: https://orcid.org/0000-0001-9412-8459)
- Yimiao Wang
- Yanli Zhang (ORCID: https://orcid.org/0000-0001-8173-2024)
- Ze Wang (ORCID: https://orcid.org/0000-0002-8339-5567)
- Sijia Chen (ORCID: https://orcid.org/0000-0001-8966-3422)
- Junying Gao (ORCID: https://orcid.org/0000-0001-9087-8789)
- Yue Li (ORCID: https://orcid.org/0000-0001-5808-6095)
- Min Cao
Institutions
- Nanjing Medical University (CN)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1186/s13195-025-01797-5
- Citations
- 1
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province