Spatial transcriptomics and multi-omics reveal relapse and resistance mechanisms of EndMT-derived CAFs mediated by TNC and FLNC in glioblastoma
These discoveries indicate that TNC and FLNC induced EndMT was a key resource of CAFs and targeting TNC and FLNC to inhibit EndMT and the collagen pathway is a promising tactic for reversing drug resistance in tumours. The development of combined chemotherapeutic strategies based on the features of tumour microenvironment endothelial cells and ECM deposition has high potential clinical value in increasing the efficacy of tumour treatment.
Authors
- Jian Zou (ORCID: https://orcid.org/0000-0003-3511-8159)
- Koukou Li (ORCID: https://orcid.org/0000-0001-7135-7638)
- Lingli Gong (ORCID: https://orcid.org/0000-0001-5863-0476)
- Die Xia (ORCID: https://orcid.org/0009-0003-7122-3789)
- Yu Zhou (ORCID: https://orcid.org/0000-0001-5284-7797)
- Bo Zhang (ORCID: https://orcid.org/0000-0002-6902-9093)
- Mei Wang (ORCID: https://orcid.org/0009-0001-4916-3789)
- Jingjing Wang (ORCID: https://orcid.org/0000-0001-5315-5469)
- Ying Yin (ORCID: https://orcid.org/0000-0002-5547-1120)
- Ji Li (ORCID: https://orcid.org/0000-0002-9075-0432)
- Zhenkun Yang (ORCID: https://orcid.org/0000-0001-5763-7748)
- Yaling Hu (ORCID: https://orcid.org/0000-0002-9985-0384)
Institutions
- Wuxi People's Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1186/s12967-025-06743-5
- Citations
- 9
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 7.18