Enhancing Early Detection of Oral Squamous Cell Carcinoma: A Deep Learning Approach with LRT-Enhanced EfficientNet-B3 for Accurate and Efficient Histopathological Diagnosis

<b>Background/Objectives:</b> Oral cancer, particularly oral squamous cell carcinoma (OSCC), ranks as the sixth most prevalent cancer globally, with rates of occurrence on the rise. The diagnosis of OSCC primarily depends on histopathological images (HIs), but this method can be time-intensive, expensive, and reliant on specialized expertise. Manual diagnosis often leads to inaccuracies and inconsistencies, highlighting the urgent need for automated and dependable diagnostic solutions to enhance early detection and treatment success. <b>Methods:</b> This research introduces a deep learning (DL) approach utilizing EfficientNet-B3, complemented by learning rate tuning (LRT), to identify OSCC from histopathological images. The model is designed to automatically modify the learning rate based on the accuracy and loss during training, which improves its overall performance. <b>Results:</b> When evaluated using the oral tumor dataset from the multi-cancer dataset, the model demonstrated impressive results, achieving an accuracy of 99.84% and a specificity of 99.92%, along with other strong performance metrics. <b>Conclusions:</b> These findings indicate its potential to simplify the diagnostic process, lower costs, and enhance patient outcomes in clinical settings.