Examining the role of freebase nicotine in the harm reduction potential of oral nicotine pouches versus moist snuff: A randomized crossover trial
The proportion of freebase nicotine in oral nicotine pouches appears to statistically significantly influence their nicotine delivery, with higher freebase nicotine oral nicotine pouches delivering more nicotine than usual brand moist snuff. However, craving appears to be higher when using oral nicotine pouches than usual brand moist snuff.
Authors
- Brittney Keller‐Hamilton (ORCID: https://orcid.org/0000-0002-8574-7263)
- Marielle C. Brinkman (ORCID: https://orcid.org/0000-0002-4315-649X)
- Kirsten Chrzan (ORCID: https://orcid.org/0009-0000-8503-125X)
- Darren Mays (ORCID: https://orcid.org/0000-0002-6605-0743)
- Hayley Curran (ORCID: https://orcid.org/0000-0002-0554-5312)
- Ahmad El‐Hellani (ORCID: https://orcid.org/0000-0002-1047-0597)
- Leanne Atkinson
- Alice Hinton (ORCID: https://orcid.org/0000-0003-4505-4021)
- Sriya Suraapaneni
- Theodore L. Wagener (ORCID: https://orcid.org/0000-0002-4028-0081)
- Clark Wilson
Institutions
- The Ohio State University Wexner Medical Center (US)
- The Ohio State University (US)
Publication Details
- Journal
- Addiction
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1111/add.70114
- Citations
- 2
- Primary Topic
- Smoking Behavior and Cessation
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- National Institute on Drug Abuse
- National Cancer Institute