Risk thresholds for soft versus hard cardiovascular disease outcome models for initiating statin therapy among Chinese adults: a cost-utility analysis
The risk threshold of 18% for soft ASCVD model and 10% for hard ASCVD model have acceptable cost-utility profiles in the Chinese population. The soft ASCVD model is more cost-effective than the hard model and should be used as a screening tool for ASCVD primary prevention.
Authors
- Robert Clarke (ORCID: https://orcid.org/0000-0002-9278-0854)
- Ling Yang (ORCID: https://orcid.org/0000-0001-5750-6588)
- Yinqi Ding (ORCID: https://orcid.org/0000-0002-0139-0261)
- Dianjianyi Sun (ORCID: https://orcid.org/0000-0003-3651-6693)
- Xiaoming Yang (ORCID: https://orcid.org/0000-0002-1792-6921)
- Canqing Yu (ORCID: https://orcid.org/0000-0002-0019-0014)
- Jun Lv (ORCID: https://orcid.org/0000-0001-7916-3870)
- Huaidong Du (ORCID: https://orcid.org/0000-0002-9814-0049)
- Yuanjie Pang (ORCID: https://orcid.org/0000-0002-4826-8861)
- Dan Huang (ORCID: https://orcid.org/0009-0001-2608-9299)
- Liming Li (ORCID: https://orcid.org/0000-0001-5873-7089)
- Haijun Zhang (ORCID: https://orcid.org/0000-0002-9958-1102)
- Zhengming Chen (ORCID: https://orcid.org/0000-0001-6423-105X)
- Junshi Chen (ORCID: https://orcid.org/0000-0001-5530-1343)
- Yiping Chen
- Maxim Barnard (ORCID: https://orcid.org/0009-0004-5160-6632)
- Zhijia Sun
- Pei Pei (ORCID: https://orcid.org/0000-0002-5741-6563)
Institutions
- Johns Hopkins University (US)
- Peking University (CN)
- University of Oxford (GB)
- China National Center for Food Safety Risk Assessment (CN)
- Hangzhou Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1186/s12916-025-04222-8
- Citations
- 1
- Primary Topic
- Health Systems, Economic Evaluations, Quality of Life
- Type
- article
- Field-Weighted Citation Impact
- 3.13
Funders
- Wellcome Trust
- National Natural Science Foundation of China
- Ministry of Science and Technology of the People's Republic of China