C4d Immunoreactivity in Autoimmune and HBV-Induced Hepatitis: Implications for Complement-Mediated Hepatocellular Injury
These data suggest an involvement of immune complex-mediated immunopathy in autoimmune hepatitis and HBV-induced hepatitis. The positive intrahepatic C4d signal was associated with heightened liver inflammation. The colocalization of the C4d signal on hepatocytes with HBsAg strongly suggests a causal relationship between viral activity and complement deposition. These observations align with our recent evidence implicating the contribution of capsid-antibody complexes in the pathogenesis of CHB.
Authors
- Min Wu (ORCID: https://orcid.org/0000-0003-1375-7638)
- Haitao Tong
- Xiaonan Zhang (ORCID: https://orcid.org/0000-0002-1286-7280)
- Ao Wang (ORCID: https://orcid.org/0000-0002-6626-8080)
- Ye Zheng (ORCID: https://orcid.org/0009-0003-8169-9326)
- Wenxing Hu (ORCID: https://orcid.org/0000-0003-2477-6383)
- Wenjuan Guo
Institutions
- University of Canberra (AU)
- Shanghai Public Health Clinical Center (CN)
Publication Details
- Journal
- Pathophysiology
- Published
- 2025-07-01
- DOI
- https://doi.org/10.3390/pathophysiology32030030
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00