Real-world effectiveness of simnotrelvir-ritonavir versus nirmatrelvir-ritonavir in hospitalized patients with COVID-19 during the omicron wave in China: a retrospective cohort study
This study illustrated that both simnotrelvir-ritonavir and nirmatrelvir-ritonavir exhibited similar effectiveness in reducing the incidence of composite disease progression, all-cause death, and the need for respiratory support amidst the real-world outbreak of the omicron VOC in China. Furthermore, simnotrelvir-ritonavir was found to be more favorable in enhancing the rate of clinical improvement in COVID-19 hospitalized patients, suggesting its potential clinical effectiveness against the disease.
Authors
- Kaicheng Liao (ORCID: https://orcid.org/0000-0002-3083-2030)
- Chuntao Li (ORCID: https://orcid.org/0000-0002-1837-0224)
- Jianqing Zhang (ORCID: https://orcid.org/0009-0003-4990-8466)
- Ying Chen (ORCID: https://orcid.org/0000-0002-5588-0397)
- Dajin Liu (ORCID: https://orcid.org/0000-0001-5617-2758)
- X. Zhang (ORCID: https://orcid.org/0000-0002-4381-6822)
- Zhongxing Liao (ORCID: https://orcid.org/0000-0002-2224-9478)
- Youlu Su (ORCID: https://orcid.org/0000-0001-7853-3163)
- Ling Liu (ORCID: https://orcid.org/0000-0002-0761-5185)
- Jinbiao Zhou
- Yuping Zhao (ORCID: https://orcid.org/0000-0003-1435-6991)
- Jiashu Li (ORCID: https://orcid.org/0000-0002-5961-7342)
- Yang Long (ORCID: https://orcid.org/0000-0002-1126-4015)
- Jiaqiang Zhang
- qingzhao cheng
- Yaling Xiang
- Yue Yang (ORCID: https://orcid.org/0000-0002-8270-9464)
Institutions
- Kunming Medical University (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1186/s12879-025-11195-9
- Citations
- 1
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Kunming Medical University
- Yunnan Provincial Science and Technology Department