TRIM24 regulates chromatin remodeling and calcium dynamics in cardiomyocytes
Our findings establish TRIM24 as a novel regulator of chromatin remodeling and cardiomyocyte transcription, directly influencing calcium homeostasis and contractility, with potential implications for cardiac disease.
Authors
- Norbert Frey (ORCID: https://orcid.org/0000-0001-7611-378X)
- Anushka Deshpande (ORCID: https://orcid.org/0009-0008-3886-2972)
- Elke Hammer (ORCID: https://orcid.org/0000-0002-1507-0402)
- Ashraf Yusuf Rangrez (ORCID: https://orcid.org/0000-0003-2630-9754)
- Ankush Borlepawar (ORCID: https://orcid.org/0000-0001-8858-1388)
- Ahmed Alameldeen (ORCID: https://orcid.org/0000-0003-2466-7515)
- Timon Seeger
- Margarete Neu
- Michael Hausmann (ORCID: https://orcid.org/0000-0001-9430-1987)
- Phillipp Vöcking
Institutions
- Heidelberg University (DE)
- Universitätsmedizin Greifswald (DE)
- University Hospital Heidelberg (DE)
- Universität Greifswald (DE)
- MSH Medical School Hamburg – University of Applied Sciences and Medical University (DE)
- German Centre for Cardiovascular Research (DE)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1186/s12964-025-02323-8
- Citations
- 3
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- Deutsches Zentrum für Herz-Kreislaufforschung
- Deutsche Forschungsgemeinschaft
- Universitätsklinikum Heidelberg