Cerebral Schistosomiasis in the Napu Valley, Central Sulawesi, Indonesia

Schistosomiasis is one of the neglected tropical diseases caused by parasitic worm infections of the genus <i>Schistosoma</i>. Involvement of the brain in schistosomiasis represents a particularly severe manifestation of the infection. Accurate diagnosis and appropriate treatment of cerebral schistosomiasis are essential, especially in our healthcare facility located in a remote area of Indonesia, where available resources are highly limited. We reported a 31-year-old female patient complaining of tonic-clonic convulsions. Before experiencing seizures, the patient reported experiencing headaches for 6 months. The patient's anamnesis regarding her social life revealed that she has been employed on a plantation for 15 years; the plantation serves as a natural habitat for snails, intermediate hosts for <i>Schistosoma</i> sp. Serological examinations were not performed due to the constraints of diagnostic instruments in the region. Cerebral schistosomiasis diagnosis was verified based on biopsy, stool examination, and CT scan results. She was admitted with a combination of steroids and praziquantel at a dosage of 60 mg/kg single dose. She was released after 14 days in satisfactory overall health. The follow-up CT scan revealed improvement, corroborated by the patient's clinical recovery. This report emphasizes the diagnostic obstacles associated with cerebral schistosomiasis, particularly in remote regions and resource-limited settings in Indonesia. Despite the absence of serological testing, a definitive diagnosis was successfully established through radiological imaging, stool microscopic examination, and brain tissue biopsy (histopathological analysis) which revealed <i>Schistosoma</i> eggs surrounded by granulomatous inflammation. The patient presented with space-occupying brain lesions and neurological symptoms, but without hepatic involvement, making the diagnosis less straightforward. This case illustrates the significance of recognizing cerebral schistosomiasis as a differential diagnosis in patients presenting cerebral lesions in endemic locations. Diagnosis of cerebral schistosomiasis based on a detailed social occupational history correlated with radiological imaging, stool microscopic examination, and brain tissue biopsy (histopathological analysis) is essential when other diagnostic tools (serological testing) are unavailable.