White Matter Hyperintensities Mediate the Negative Impact of HbA1c Levels on Cognitive Function
This study suggests that WMHs partially mediate the association between chronically elevated blood glucose levels and cognitive impairment in neurologically healthy adults, supporting a potential microvascular mechanism in diabetes-related cognitive impairment.
Authors
- Julius Fridriksson (ORCID: https://orcid.org/0000-0001-9255-2045)
- Heather Shaw Bonilha (ORCID: https://orcid.org/0000-0002-3581-4202)
- Natalie Busby (ORCID: https://orcid.org/0000-0001-7117-7899)
- Roger Newman‐Norlund (ORCID: https://orcid.org/0000-0002-0966-1070)
- Sarah Newman‐Norlund (ORCID: https://orcid.org/0000-0002-9064-1332)
- Ida Rangus (ORCID: https://orcid.org/0000-0001-9189-8941)
- Chris Rorden (ORCID: https://orcid.org/0000-0002-7554-6142)
- Janina Wilmskoetter (ORCID: https://orcid.org/0000-0002-1083-7301)
- Nicholas Riccardi (ORCID: https://orcid.org/0000-0001-7243-6100)
- Rufus A. Johnstone (ORCID: https://orcid.org/0000-0002-7155-6124)
Institutions
- Medical University of South Carolina (US)
- University of South Carolina (US)
- Columbia University (US)
Publication Details
- Journal
- Brain Sciences
- Published
- 2025-06-27
- DOI
- https://doi.org/10.3390/brainsci15070692
- Primary Topic
- Neonatal and fetal brain pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of South Carolina
- School of Medicine, University of South Carolina