Within-host population dynamics of extensively drug-resistant <i>Mycobacterium tuberculosis</i> revealed by an over 3-year longitudinal study
The microevolution of drug-resistant MTB within patients on long-term ineffective treatment is complex. Subpopulations with different resistance-conferring mutations can compete with each other and with newly emerged subpopulations. Often, one subpopulation eventually dominates and achieves long-term stability. This work deepens the understanding of MTB microevolution in XDR-TB patients.
Authors
- Wenjie Lai (ORCID: https://orcid.org/0009-0009-4735-9970)
- Guofang Deng (ORCID: https://orcid.org/0000-0003-2479-3327)
- Peize Zhang (ORCID: https://orcid.org/0000-0002-4023-0228)
- Jiuxin Qu (ORCID: https://orcid.org/0000-0003-1061-2353)
- Senlin Zhan
- Qian Gao (ORCID: https://orcid.org/0000-0002-8489-3672)
- Liyong Liu (ORCID: https://orcid.org/0000-0002-5410-9541)
- Xuecong Zhang (ORCID: https://orcid.org/0000-0001-6584-4923)
- Jialei Liang
- Howard Eugene Takiff (ORCID: https://orcid.org/0000-0002-0480-0860)
- Dan Li (ORCID: https://orcid.org/0000-0002-5567-6927)
- Peng Xu (ORCID: https://orcid.org/0000-0002-3503-6017)
- Chi Wu (ORCID: https://orcid.org/0009-0006-8841-1796)
- Yiwang Chen (ORCID: https://orcid.org/0009-0009-3042-2144)
- Ruimin Hong
Institutions
- Shanghai Medical College of Fudan University (CN)
- Instituto Venezolano de Investigaciones Científicas (VE)
- Southern University of Science and Technology (CN)
- National Clinical Research (US)
- Shenzhen Third People’s Hospital (CN)
Publication Details
- Journal
- Evolution Medicine and Public Health
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/emph/eoaf014
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shenzhen Science and Technology Innovation Program