Unlocking nature’s potential: Neuropharmacological effect of Polyherbal fruit peel extracts against depression

Problem statement: Depression is distinguished by a depressive mood, a loss of interest or pleasure, a sense of guilt, low self-esteem, sleep problems, loss of appetite, low energy, and difficulty concentrating. This widespread mental condition can affect anyone regardless of gender, age, or background. People treat it with psychotherapy and medicines. Alternatively, some people employ herbal therapies for treatment. Natural herbal remedies with antidepressant properties have recently gained popularity in the marketplace. Banana peel (Musa paradisiaca) is often used to treat warts, as a diuretic, to aid in detoxification, and to relieve hangovers, while pineapple peel (Ananas comosus) has antifungal, antibacterial, anti-inflammatory, and anti-coagulant properties. The current study investigated the anti-depressant efficacy of a polyherbal extract derived from banana and pineapple peels. Approach: Acute Toxicity Studies (ATS) were conducted with Swiss albino mice of either sex weighing approximately 28-30 gms. Six rats from four groups received four different treatments (normal saline 5 mL kg−1, polyherbal peel extract 200 and 400 mg kg−1, and Imipramine 20mg kg−1, p.o.) for 7 days before being submitted to Forced Swim Test (FST) and Tail Suspension Test (TST). Results: The result were shown that polyherbal peel extract 400 mg kg−1 significantly matches the standard in terms of duration of immobility.