Studying the level of TNF-α cytokine in patients with diabetic neuropathy

The aim of the study. To investigate the relationship between the content of TNF-α in the blood of patients with diabetes and the development of diabetic neuropathy. Materials and Methods. Type 2 DM2 patients without complications and patients with diabetic neuropathy (DN) under inpatient treatment in RSSPMC of endocrinology of HM RUz participated in the study. Biochemical analysis and TNF-α cytokine were determined in blood. Results and discussion. The results of determining the content of TNF-α in the blood serum of the studied groups using ELISA showed that in patients with diabetes there is a significant increase in the content of TNF-α (3.05±0.44 pg/ml) relative to the values in the control group. In the group of patients with DN, an increase in the concentration of TNF-α in the blood serum was observed, which amounted to 5.2±0.44 pg/ml. A study of the concentration of TNF-α in patients without complications of diabetes and in patients with DN mild degree did not reveal statistically significant differences. In patients with DN mild degree, the average concentration of TNF-α was 3.62±0.89 pg/ml, and in DN severe degree -7.13±1.14 pg/ml, i.e. increased almost 2 times. Conclusion. It was found that the content of TNF-α in the serum of patients with diabetic neuropathy is in direct correlation with the degree of severity of the disease. Funding: by Mininnovation.uz and WorldBank ФЗ-2020092959 (Ф-ОТ-2021-153) This abstract was presented at the American Physiology Summit 2025 and is only available in HTML format. There is no downloadable file or PDF version. The Physiology editorial board was not involved in the peer review process.