Deep learning volumetrics reveal distinct clinical trajectories for pediatric low-grade gliomas under surveillance: A multicenter study
Deep learning enables systematic, longitudinal, pLGG growth tracking and characterization of patients on surveillance, yielding insights into untreated tumor trajectories and progression risk. This pipeline is useful at population-level to study growth trends and at patient-level to guide personalized management.
Authors
- Hugo J.W.L. Aerts (ORCID: https://orcid.org/0000-0002-2122-2003)
- Tina Young Poussaint (ORCID: https://orcid.org/0000-0002-0814-0791)
- Keith Lloyd Ligon (ORCID: https://orcid.org/0000-0002-7733-600X)
- Ariana Familiar (ORCID: https://orcid.org/0000-0002-9315-8653)
- Benjamin H. Kann (ORCID: https://orcid.org/0000-0002-4313-2754)
- Sridhar Vajapeyam (ORCID: https://orcid.org/0000-0002-1782-1919)
- Anna Zapaishchykova (ORCID: https://orcid.org/0000-0001-6860-9160)
- John Zielke
- Shahrooz Faghihroohi
- Ali Nabavizadeh (ORCID: https://orcid.org/0000-0002-0380-4552)
- Daphne Adele Haas-Kogan (ORCID: https://orcid.org/0000-0002-2378-4800)
- Pratiti Bandopadhayay (ORCID: https://orcid.org/0000-0002-4175-4760)
- Aidan Boyd (ORCID: https://orcid.org/0000-0001-9756-0570)
- Zezhong Ye (ORCID: https://orcid.org/0000-0003-0369-7432)
- Franziska Michor (ORCID: https://orcid.org/0009-0003-8552-7767)
- Divyanshu Tak
- Maryam Mahootiha
- Ceilidh Smith
- Sabine Mueller (ORCID: https://orcid.org/0000-0002-8216-9357)
- Juan Carlos Pardo
- Jacquelyn Jones
Institutions
- Brigham and Women's Hospital (US)
- Boston Children's Hospital (US)
- Pennsylvania State University (US)
- Children's Hospital of Philadelphia (US)
- Harvard University (US)
- University of California, San Francisco (US)
- Maastricht University (NL)
- California University of Pennsylvania (US)
- Dana-Farber Cancer Institute (US)
- Boston Children's Museum (US)
- Dana-Farber Brigham Cancer Center (US)
- Artificial Intelligence in Medicine (Canada) (CA)
- Mass General Brigham (US)
- Technical University of Munich (DE)
- University of Pennsylvania (US)
Publication Details
- Journal
- Neuro-Oncology Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/noajnl/vdaf145
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- William M. Wood Foundation
- National Institutes of Health
- National Cancer Institute