Effects of Whole-body Vibration Training and Vitamin D Supplementation on Muscle Quality and Bone Density in the aged with osteo-sarcopenia: a randomized controlled trial

This research endeavors to probe into the impacts of whole-body vibration training (WBVT) in conjunction with vitamin D (Vit. D) supplementation on muscle quality and bone density among elderly individuals suffering from osteo-sarcopenia (OS). OS is a widespread geriatric syndrome that markedly compromises the quality of life in the elderly populace; however, research on its mechanisms and targeted pharmacological interferences is currently constrained. Muscles and bones interact via mechanical and chemical processes, and elucidating these interactions can contribute to the prevention and treatment of musculoskeletal disorders. In this investigation, we propose to quantify the levels of myokines irisin and myostatin (MSTN) in the serum of clinical subjects, while implementing WBVT combined with Vit. D supplementation as an intervention for OS patients. Dual-energy X-ray absorptiometry (DXA) will be employed to assess bone mineral density and muscle mass, while grip strength meter and 5-time chair stand test will be utilized to evaluate muscle strength. Additionally, 6-meter walk speed, Short Physical Performance Battery, and Timed Up and Go test will be used to assess physical function. The study will analyze the correlation between irisin/MSTN and OS, as well as the clinical efficacy and mechanism of action of WBVT combined with Vit. D in alleviating OS. The objective is to enhance the clinical diagnosis rate of OS, prevent OS complications at an early stage, facilitate the development of targeted pharmacological interventions for OS, provide a scientific basis for clinical diagnosis and treatment, improve the quality of life of the elderly, reduce the societal medical and economic burden, and make a substantial contribution to advancing medical and health technology in China. This trial was funded by the Program of National Natural Science Foundation of China (82474543 to FY), the Program of Shaanxi Province Natural Science Foundation (2023-YBSF-210 to FY & 2023-JC-QN-0978 to WL), the Program of Shaanxi Administration Bureau of Traditional Chinese Medicine (2021-01-22-009 to FY & 2022-QCYZH-029 to WL), Youth Innovation Team in Shaanxi universities, and the Program of Health Commission of Shaanxi Province (2022B002 to WL). Shaanxi Province Natural Science Foundation (2023-JC-QN-0978), and Shaanxi Administration Bureau of Traditional Chinese Medicine (2022-QCYZH-029) This abstract was presented at the American Physiology Summit 2025 and is only available in HTML format. There is no downloadable file or PDF version. The Physiology editorial board was not involved in the peer review process.