Methylation of LINE-1 Retroelement in People with Type 1 Diabetes

PwT1D were found to have higher total LINE-1 methylation rate (mC) compared to healthy controls. The partial methylation pattern (uCmC) was less frequently observed in these patients and was negatively associated with the glycemic status and the age at diagnosis of T1D, while demonstrating a positive correlation with disease duration.

Authors

Ioannis Georgiou (ORCID: https://orcid.org/0000-0002-0308-5703)
Agathocles Tsatsoulis
Stelios Tigas (ORCID: https://orcid.org/0000-0001-7325-8983)
Evangelos Liberopoulos (ORCID: https://orcid.org/0000-0002-7162-3323)
Charilaos Kostoulas (ORCID: https://orcid.org/0000-0002-0769-0257)
Andromachi Katsanou

Institutions

University of Ioannina (GR)
National and Kapodistrian University of Athens (GR)
General Hospital of Ioannina G. Hatzikosta (GR)
Laiko General Hospital of Athens (GR)

Publication Details

Journal: Genes
Published: 2025-06-28
DOI: https://doi.org/10.3390/genes16070759
Primary Topic: Pancreatic function and diabetes
Type: article
Field-Weighted Citation Impact: 0.00

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article

Methylation of LINE-1 Retroelement in People with Type 1 Diabetes

Ioannis Georgiou, Agathocles Tsatsoulis, Stelios Tigas, Evangelos Liberopoulos et al.

Jun 28, 2025

Genes

Pancreatic function and diabetes

article

Methylation of LINE-1 Retroelement in People with Type 1 Diabetes

Ioannis Georgiou, Agathocles Tsatsoulis, Stelios Tigas, Evangelos Liberopoulos, Charilaos Kostoulas, Andromachi Katsanou

June 28, 2025article en

Abstract

PwT1D were found to have higher total LINE-1 methylation rate (mC) compared to healthy controls. The partial methylation pattern (uCmC) was less frequently observed in these patients and was negatively associated with the glycemic status and the age at diagnosis of T1D, while demonstrating a positive correlation with disease duration.

GenesVol. 16(7)

University of Ioannina (GR), National and Kapodistrian University of Athens (GR), General Hospital of Ioannina G. Hatzikosta (GR), Laiko General Hospital of Athens (GR)

Good health and well-being

Openalex Percentile: Top 73%

Pancreatic function and diabetes

DOI Open Access PDF OpenAlex

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Methylation of LINE-1 Retroelement in People with Type 1 Diabetes — Ioannis Georgiou, Agathocles Tsatsoulis, et al. · Genes (2025) | TGRS Research Map | TGRS