MIF-mediated crosstalk between THRSP+ hepatocytes and CD74+ lipid-associated macrophages in hepatic periportal zone drives MASH
Our study demonstrates that THRSP drives MASH progression by recruiting CD74 + LAMs mediated by MIF in the hepatic PP zone, providing novel insights into the spatial zonation and crosstalk between lipogenic hepatocytes and LAMs that may result in novel therapies for MASH.
Authors
- Jundong Yang
- Zhenfei Gao (ORCID: https://orcid.org/0000-0002-0949-5084)
- Shankai Yin (ORCID: https://orcid.org/0000-0003-3689-8599)
- Yuenan Liu (ORCID: https://orcid.org/0000-0002-4635-0634)
- Haolin Yuan
- Weijun Huang (ORCID: https://orcid.org/0000-0002-2704-4674)
- Jianwei Shuai (ORCID: https://orcid.org/0000-0002-8712-0544)
- Sheng-Ming Wang (ORCID: https://orcid.org/0000-0002-4374-6756)
- Na Li (ORCID: https://orcid.org/0009-0001-9511-2384)
- Qing Li (ORCID: https://orcid.org/0000-0002-6464-0977)
- Feng Liu (ORCID: https://orcid.org/0000-0003-3228-0943)
- Junli Liu (ORCID: https://orcid.org/0000-0001-8861-3706)
- Wei Wang (ORCID: https://orcid.org/0000-0001-7492-6795)
- Hangdong Shen (ORCID: https://orcid.org/0009-0008-0314-9122)
- Hai Lin (ORCID: https://orcid.org/0000-0002-3498-8059)
- Hai-Liang Li
- Wenjun Xue
- Xu Xu (ORCID: https://orcid.org/0000-0002-8958-5302)
Institutions
- Shanghai Jiao Tong University (CN)
- Capital Medical University (CN)
- Wenzhou Medical University (CN)
- Zhejiang Lab (CN)
- Shanghai Sixth People's Hospital (CN)
- Beijing Friendship Hospital (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Hepatology
- Published
- 2025-06-12
- DOI
- https://doi.org/10.1097/hep.0000000000001429
- Citations
- 5
- Primary Topic
- Macrophage Migration Inhibitory Factor
- Type
- article
- Field-Weighted Citation Impact
- 3.99