Study of bacteriological diagnosis and some biochemical parameters in PTB patient who receiving Anti-tuberculosis drugs

Background: Anti-tuberculosis drugs can cause harmful effects on the health of a PTB patient and thus cause harmful interference with various vital body functions. Methods: In this study, 80 PTB patients (43 men and 37 female) were randomly assigned, and 40 healthy people (21 men and 19 female) were used as the control group. The findings indicated that males (53.75%) were more likely than females (46.25%) to be infected with pulmonary tuberculosis. Results: The result of statistical analysis showed a significantly increased serum level of urea, TSB, and sodium in the PTB patients group compared to the control. The mean ±SD of serum urea, TSB, and sodium for the patient respectively were 34.14±4.19, 0.669±0.21 and 142.98±14.837. There was a significant positive correlation between serum GOT and serum GPT (r=0.573, p<0.0001) as well as serum ALP (r=0.258, p<0.0001) in PTB patients (N=80). Similarly, the correlation between serum sodium and serum potassium was positive and significant (r=0.200, p=0.021). Conclusions: Anti-tuberculosis drug-treated tuberculosis was linked with a significant increase in serum urea, TSB, and sodium and a significant decrease in serum potassium in this study. Therefore, in patients who receive anti-tuberculosis drugs, there is a chance that the increase and decrease in serum biochemical parameter levels will have an adverse influence on body functions. Objectives: In considering this, the current study's goal was to investigate the side effects of anti-tuberculosis drugs on liver and kidney functions and some electrolytes for PTB patients who take these drugs.