Safety profile of topical spray minoxidil: An observational study

Topical minoxidil is a widely used treatment for various hair loss disorders, including androgenetic alopecia, telogen effluvium, and alopecia areata. While its efficacy is well established, concerns remain regarding its tolerability and side effect profile. This cross-sectional study evaluated 105 minoxidil users via an online questionnaire to assess the prevalence and nature of adverse effects. The majority of participants were female (67.6%) with a mean age of 36.5 years. Most used a 2% solution applied once daily, primarily for AGA and telogen effluvium. Overall, 72% of users reported at least one adverse effect, most commonly scalp irritation (36.2%), facial hypertrichosis (21.9%), and dandruff (18%). Systemic side effects, including palpitations and hypotension, were reported by a minority. Despite the high rate of side effects, only 20% discontinued treatment. Prolonged use was associated with better adherence, suggesting improved tolerance over time. These findings underscore the importance of monitoring for dermatologic and systemic side effects and exploring alternative formulations or therapies for sensitive individuals.