ASSESSMENT OF THE QUALITY OF LIFE IN PATIENTS WITH COVID-19

Purpose: of this study was aimed at studying the quality of life of patients after COVID-19 and the correlation of subscales according to the SF-36 quality of life questionnaire and the level of phosphorylated neurofilaments.Materials and methods. The study included 100 patients, who were divided into 2 groups: the main and control, patiens age from 19 to 60 years, gender composition was dominated by men - 60 people. The main group included patients with a confirmed diagnosis of COVID-19 and who received treatments in hospital or at the family doctor in the ambulance. The control group included patients who did not have this disease. All participants of the study underwent a clinical and neurological examination, an assessment of cognitive functions was carried out according to the MoCA scale; Luria's 10 Word Test; Schulte tables; development of depression using the Beck questionnaire, indicators of situational and personal anxiety on the Spielberger scale. Quality of life assessment was carried out in patients who had COVID-19 using a questionnaire «SF-36».The level of phosphorylated neurofilament has also been determined as a predictor of the development of neurodegenerative diseases.Subsequently, the patients of the main group (n = 69) were divided into 2 subgroups depending on the level of neurofilament: the first subgroup of NfL-N with a concentration not exceeding normal and the second subgroup of NfL-P with a concentration above normal.Results. The result of the study showed a direct strong relationship between the indicator of the physical component of the questionnaire "SF-36" and the indicator on the MoCA scale and a direct relationship between the average strength according to the result according to the Luria test, the feedback relationship between the physical component of the questionnaire "SF-36" and the indicator obtained on the Beck scale of depression, as well as the level of situational and personal anxiety on the Spielberger scale.The number of scores on the physical component of the quality of life questionnaire also decreased with the increase in scores on the Beck and Spielberger scale. The number of scores on the physical component of the quality of life questionnaire also decreased with the increase in scores on the Beck and Spielberger scale. When re-examined 6 months after COVID-19, the mental component was reliably associated with all the psycho-emotional characteristics studied, and the direction of communication was similar to the correlation with the physical component, but the strength on all was less. After 6 months of follow-up, the mental component of the SF-36 questionnaire was reliably associated with all psycho-emotional characteristics studied, and the direction of communication was similar to the correlation with the physical component, but the strength for all was less. Conclusions. At re-examination after 6 months, the physical component was directly correlated with overall MoCA scores (mean correlation strength) and Luria test scores (strong correlation), as well as inversely proportional to the overall score on the Beck Depression Scale (mean correlation strength) and situational and personal anxiety on the Spielberger scale (strong correlation for both subscales).