Thioguanine-coordinated assembly for synthetic lethality of colorectal cancer with defective mismatch repair
A thioguanine-coordinated metal-organic polymer was designed for the carrier-free co-delivery of thioguanine and Werner syndrome helicase (WRN) inhibitor to induce synthetic lethality in colorectal cancer cells with defective mismatch repair. Upon glutathione-triggered disassembly of the nanovector, the released thioguanine and WRN inhibitor concurrently disrupted both primary and compensatory DNA damage response pathways, achieving significant synthetic lethality.
Authors
- Jianping Lei (ORCID: https://orcid.org/0000-0002-3594-180X)
- Yang Zhou (ORCID: https://orcid.org/0000-0003-3072-271X)
- Lina Wu (ORCID: https://orcid.org/0000-0001-8640-6279)
- Taikang Wu
- Zhiyuan Xu (ORCID: https://orcid.org/0000-0001-6026-9800)
- Xiang Xu (ORCID: https://orcid.org/0009-0009-9282-2098)
Institutions
- Nanjing Normal University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc01724f
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China