Successful Treatment of Anemia With Ringed Sideroblasts Induced by Antidepressants Through Vitamin B6 Supplementation and Discontinuation of Antidepressants
Vitamin B6 (VB6) is a vital coenzyme for δ-aminolevulinic acid synthase (ALAS) in heme biosynthesis. We report a 49-year-old male with severe microcytic anemia and ringed sideroblasts initially diagnosed as myelodysplastic syndrome (MDS). VB6 deficiency, attributed to long-term amoxapine use, was identified. His anemia improved significantly with VB6 supplementation and resolved completely after discontinuing amoxapine. This case highlights the need to consider VB6 deficiency in anemia with ringed sideroblasts.
Authors
- Sanshiro Nakao
- Naomi Shimizu (ORCID: https://orcid.org/0000-0001-8295-8893)
- Chiaki Nakaseko (ORCID: https://orcid.org/0000-0003-1175-226X)
- Ayaki Tanaka
- Chikako Ohwada (ORCID: https://orcid.org/0000-0001-9648-940X)
- Asuka Shibamiya (ORCID: https://orcid.org/0000-0002-6327-5322)
- Reiko Watanabe (ORCID: https://orcid.org/0000-0003-4655-4407)
- Keisuke Kirito
Institutions
- Toho University (JP)
- Chiba University Hospital (JP)
- Toho University Medical Center Sakura Hospital (JP)
- International University of Health and Welfare (JP)
Publication Details
- Journal
- Case Reports in Hematology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1155/crh/7046013
- Primary Topic
- Porphyrin Metabolism and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00