Successful Conversion Surgery for Unresectable Microsatellite Instability–High Pancreatic Tail Cancer Following Pembrolizumab Therapy
The present rare case of conversion surgery for MSI-high UR-M pancreatic tail cancer, achieving a pathological partial response after pembrolizumab treatment, highlights the potential of pembrolizumab against this specific molecular subtype of pancreatic cancer and underscores the clinical significance of proactively testing for MSI to identify candidates for immunotherapy and curative conversion surgery.
Authors
- Hiroko Okinaga
- Chikara Shirata (ORCID: https://orcid.org/0009-0008-0928-0869)
- Shinichiro Horiguchi
- Toshihiro Okuya
- Yasuji Seyama (ORCID: https://orcid.org/0000-0001-9295-495X)
- Nobuhiro Harada
- Mizuka Suzuki (ORCID: https://orcid.org/0000-0002-7955-0835)
- Masanao Kurata (ORCID: https://orcid.org/0000-0002-1273-9051)
Institutions
- Tokyo Metropolitan Komagome Hospital (JP)
Publication Details
- Journal
- Surgical Case Reports
- Published
- 2025-01-01
- DOI
- https://doi.org/10.70352/scrj.cr.25-0174
- Citations
- 1
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.05