An mRNA Vaccine Expressing Blood-Stage Malaria Antigens Induces Complete Protection Against Lethal Plasmodium yoelii
mRNA vaccines were highly immunogenic and potently protective against blood-stage malaria, outperforming a similar recombinant-based vaccine. The membrane-bound antigen was more effective at inducing protective antibody responses, highlighting the need to consider antigen localization for mRNA vaccine design.
Authors
- Amy C. Ott
- Patrick J. Loll (ORCID: https://orcid.org/0000-0001-5416-4500)
- James M. Burns (ORCID: https://orcid.org/0000-0002-6431-141X)
Institutions
- Drexel University (US)
Publication Details
- Journal
- Vaccines
- Published
- 2025-06-28
- DOI
- https://doi.org/10.3390/vaccines13070702
- Citations
- 2
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 3.76