EXPERIMENTAL STUDY ON HEPATOPROTECTIVE ACTIVITY OF SHIRISHADI YOGA IN ACETAMINOPHEN INDUCED HEPATOTOXICITY IN SD (SPRAGUE-DAWLEY) RATS

The liver, a critical organ for metabolism, detoxification, and homeostasis, is vulnerable to damage from toxins, including acetaminophen, a widely used analgesic and antipyretic drug. Excessive or prolonged acetaminophen use can induce severe hepatotoxicity, marked by oxidative stress, inflammation, and hepatic necrosis. Traditional medicinal systems like Ayurveda provide potential remedies for liver disorders. Shirishadi Yoga, a polyherbal Ayurvedic formulation, incorporates herbs such as Shirisha (Albizia lebbeck) and Haridra (Curcuma longa), celebrated for their hepatoprotective, detoxifying, and antioxidant effects. These herbs are thought to alleviate liver damage by reducing inflammation, neutralizing oxidative stress, and promoting tissue regeneration. This study investigates the hepatoprotective efficacy of Shirishadi Yoga against acetaminophen-induced liver injury. It assesses the formulation’s ability to mitigate oxidative damage, normalize liver enzyme levels, and prevent histopathological changes in the liver. By leveraging its natural therapeutic properties, Shirishadi Yoga could emerge as a viable alternative for managing drug-induced hepatotoxicity, offering a holistic approach to liver health restoration and protection.