Association of Striatal Dopaminergic Depletion and Cerebral Perfusion With Cognition in Brain-First and Body-First Parkinson’s Disease
This study demonstrated that the patterns of striatal subregional dopamine depletion and regional cerebral perfusion differed between the brain-first and body-first PD subtypes, and these differences largely mediated inter-subtype differences in cognitive outcome.
Authors
- Seong Ho Jeong (ORCID: https://orcid.org/0000-0003-4439-4390)
- Yong Jeong (ORCID: https://orcid.org/0000-0002-5907-3787)
- Hye Sun Lee (ORCID: https://orcid.org/0000-0001-6328-6948)
- Phil Hyu Lee (ORCID: https://orcid.org/0000-0001-9931-8462)
- Yun Joong Kim (ORCID: https://orcid.org/0000-0002-2956-1552)
- Young H. Sohn (ORCID: https://orcid.org/0000-0001-6533-2610)
- Seok Jong Chung (ORCID: https://orcid.org/0000-0001-6086-3199)
- Su Hong Kim (ORCID: https://orcid.org/0000-0003-2128-3524)
- Chan Wook Park
Institutions
- Yong In University (KR)
- Korea Advanced Institute of Science and Technology (KR)
- Yonsei University (KR)
- Severance Hospital (KR)
- University Health System (US)
- Korea Institute of Brain Science (KR)
- Institute of Cognitive and Brain Sciences (US)
- Yonsei University Health System (KR)
- Yeungnam University College
- Yeungnam University (KR)
Publication Details
- Journal
- Clinical Nuclear Medicine
- Published
- 2025-06-30
- DOI
- https://doi.org/10.1097/rlu.0000000000005922
- Citations
- 2
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.78