Tranexamic acid impairs plasmin generation on human mesenchymal stem cells and derived membrane microvesicles, halting pericellular proteolysis
We propose that plasmin formation on MSCs may be involved in pathological processes such as endometrial hemorrhage (metrorrhagia and Post-Partum Hemorrhage), autoimmune and ischaemic diseases, as well as cancer. By advancing our understanding of these mechanisms, we open new avenues for the development of biomarkers and targeted treatments.
Authors
- Fatiha Zoubari El-Ghazouani
- Audrey Cras
- Eduardo Anglés‐Cano (ORCID: https://orcid.org/0000-0001-7891-3975)
- Florence Toti (ORCID: https://orcid.org/0000-0001-5843-2816)
- Ramy Abou Rjeily
- Christina Mrad
Institutions
- Délégation Paris 5 (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Regenerative NanoMedicine (FR)
- Sorbonne Paris Cité (FR)
- Université de Strasbourg (FR)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-06-30
- DOI
- https://doi.org/10.3389/fmed.2025.1570395
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale