Narirutin treatment accelerates the process of diabetic wound repair by regulating phenotype switching of macrophages through affecting metabolic reprogramming
Our study discovered that macrophages repolarization to M2 phenotype was required for Nar-induced promotive effects on diabetic wound repair by regulating reprogramming of glucose metabolism via mediating AMPK/Mfn2 pathway, providing a promising strategy for DFU management.
Authors
- Li Lü (ORCID: https://orcid.org/0000-0002-3905-1273)
- Liang Liu (ORCID: https://orcid.org/0000-0002-7073-0717)
- Haiyan Liu (ORCID: https://orcid.org/0000-0002-4652-469X)
- Jing Lu (ORCID: https://orcid.org/0009-0005-0892-6689)
- Juan Zhou (ORCID: https://orcid.org/0000-0002-1066-1262)
- Han Wang (ORCID: https://orcid.org/0000-0003-2420-3147)
- Yan Zhang (ORCID: https://orcid.org/0000-0002-5022-362X)
Institutions
- Peking University (CN)
- Hubei Provincial Hospital of Traditional Chinese Medicine (CN)
- Peking University People's Hospital (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-06-30
- DOI
- https://doi.org/10.3389/fphar.2025.1614967
- Citations
- 3
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.08
Funders
- China Postdoctoral Science Foundation