Intermittent supplementation with Akkermansia muciniphila and galactooligosaccharides modulates Alzheimer’s disease progression, gut microbiota, and colon short-chain fatty acid profiles in mice
These findings suggest that long-term administration of <i>A. muciniphila</i> and GOS effectively improves metabolic health and modulates symptoms of AD in the APP/PS1 mouse model.
Authors
- Miguel Gueimonde (ORCID: https://orcid.org/0000-0002-0192-901X)
- Aurelijus Burokas (ORCID: https://orcid.org/0000-0002-0364-3496)
- Rolandas Meškys (ORCID: https://orcid.org/0000-0003-3125-9827)
- Alessandro Atzeni (ORCID: https://orcid.org/0000-0002-1804-8606)
- Daiva Baltriukienė (ORCID: https://orcid.org/0000-0002-7851-9270)
- Akshay Kumar Vijaya (ORCID: https://orcid.org/0009-0000-5106-7983)
- Silvia Arboleya (ORCID: https://orcid.org/0000-0002-6155-5822)
- Jonas Mingaila (ORCID: https://orcid.org/0009-0006-5214-0189)
- Rapolas Jamontas
- Arnas Kunevičius (ORCID: https://orcid.org/0009-0000-8165-912X)
- Ieva Šimoliūnė
- Emilija Keževičiūtė
Institutions
- Vilnius University (LT)
- Instituto de Productos Lácteos de Asturias (ES)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-06-30
- DOI
- https://doi.org/10.3389/fnagi.2025.1617980
- Citations
- 3
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Lietuvos Mokslo Taryba