Shifting landscapes: dynamic changes from pro- to anti-inflammatory leukocyte phenotype in myocardial ischemia/reperfusion injury
The present study demonstrates that both anti-inflammatory Ly6C<sup>low</sup> monocytes and N2 neutrophils participate in PLC formation following myocardial infarction (MI) and reperfusion. Our results suggest that the N2 phenotype prerequisite for PLC formation in AAR at day 7. These findings suggest that targeted interventions may be developed to improve outcomes after myocardial I/R injury.
Authors
- Nancy Schanze (ORCID: https://orcid.org/0000-0002-4012-103X)
- Nadine Gauchel (ORCID: https://orcid.org/0000-0002-1276-9920)
- Pia Kröning
- Dirk Westermann (ORCID: https://orcid.org/0000-0002-7542-1956)
- Daniela Stallmann
- Daniel Duerschmied (ORCID: https://orcid.org/0000-0001-5249-4012)
- Maximilian Mauler
- K Naber
Institutions
- Heidelberg University (DE)
- University Medical Center Freiburg (DE)
- University Hospital Heidelberg (DE)
- German Centre for Cardiovascular Research (DE)
- Universitäts-Herzzentrum Freiburg-Bad Krozingen (DE)
- University Medical Centre Mannheim (DE)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-06-30
- DOI
- https://doi.org/10.3389/fcvm.2025.1596538
- Primary Topic
- Cardiac Ischemia and Reperfusion
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsches Zentrum für Herz-Kreislaufforschung
- Deutsche Forschungsgemeinschaft