Research Progress on the Synthesis of 2H-Chromene Compounds

2H-色烯化合物是一类含有氧原子的杂环化合物，广泛存在于天然产物中，表现出抗菌、抗炎、抗氧化、抗癌等活性，在合成化学和化学生物学中，2H-色烯骨架也是重要的合成砌块。因此发展高效合成2H-色烯的方法具有良好的研究价值和应用前景。目前合成2H-色烯的方法有分子内环化反应和分子间环加成反应，分子间环加成反应可细分为分子间[3 + 3]和分子间[4 + 2]反应。本文主要介绍了近年来通过分子内环化反应和分子间环加成反应合成2H-色烯的方法，为这一类化合物的合成研究提供借鉴。2H-chromene compounds are a class of heterocyclic compounds containing oxygen atoms, widely present in natural products. They exhibit activities such as antibacterial, anti-inflammatory, antioxidant, and anticancer properties. In synthetic chemistry and chemical biology, 2H-chromene skeleton is also an important synthetic block. Therefore, developing efficient method for synthesizing 2H-chromenes has good research value and application prospects. Currently, methods for synthesizing 2H-chromenes are divided into intramolecular cyclization reactions and intermolecular cycloaddition reactions. Intermolecular cycloaddition reactions can be further subdivided into intermolecular [3 + 3] and [4 + 2] reactions. This article mainly introduces recent methods for synthesizing 2H-chromenes through intramolecular cyclization and intermolecular cycloaddition reactions, providing a reference for the synthetic research of this class of compounds.